Figure 2

We performed logistic regression with 19 RNA-seq datasets and the domain-domain interaction database to construct IIIDB. In RNA-seq data processing, Bowtie2 and eXpress were used to calculate isoform expressions. To confirm with PPI, given an III prediction I1 and I2, we only keep this isoform interaction if the gene symbols of I1 and I2 have PPI in IntAct database.