Figure 1

Comparison of pig and human genetic architecture of anemia related traits such as mean corpuscular hemoglobin (MCH). a) Pig SNP association result for MCH. There is a strong QTL at chromosome 8 along with 11 other significant QTLs. The black line represents a p-value threshold 4.85 × 10⁻⁶, corresponding to FDR = 0.05. b). Both pig genome wide association candidates (blue nodes) and human GWAS candidate (red nodes) for MCH are in a liver subnetwork that involves in lipid metabolism. Hepcidin (HAMP, yellow node) is a sensor for iron and inflammation. The subnetwork provides a molecular link between anemia and lipid metabolism.