Fig. 5
From: Negative selection maintains transcription factor binding motifs in human cancer
Relative location of mutated bases in reference to the AP2A (top panel) and ESR1 (bottom panel) binding motifs predicted for breast cancer data. Y axis shows the relative fraction of mutation-centered windows with the legitimate motif predictions, X axis shows the location of a mutated base relative to the motif. Motif logos are scaled according to the discrete information content. Somatic variants tend to localize at strict position of the AP2A motif (red line) leading to affinity change. Variants in ESR1 motif (purple line) avoid strict and prefer degenerate positions, the motif is protected from affinity change