Fig. 2

Distribution of HVR1 variants by DNA PhyChem property. Shown are binned plots of 5681 HVR1 PhyChem variants derived from 222 patients. Y-axis denotes fraction (percent) of variants with same range of values (x-axis) for PhyChem indexes: (a) Twist_tilt, (b) Slide_rise, (c) Enthalpy, (d) Breslauer_dH and (e) Sugimoto_dH. The Sugimoto_dH index illustrates an example of a DNA PhyChem property found to have small but significant correlation (r = 0.102; p < 1.38 × 10−14) to the R/C classes. R- and C-associated variants are denoted in red and blue, respectively