Fig. 1
Differences in cis- regulation of GTF2I exon 18, between ancestral TE present and derived TE absent states of GTF2I. Visualization of the target region with chromosomal coordinates in Mb (top line) along canine chromosome CFA6 for Capture C contacts (top), average E2F1 ChIP-Seq Coverage (middle) with differential peak (*), and average normalized exon expression with exon 18 (§) values at GTF2I (bottom) for samples A heterozygous for the ancestral TE insertion in GTF2I and B homozygous for the derived allele lacking the TE insertion in GTF2I. For panels C-E, the ancestral state refers to the TE insertion in GTF2I, while the derived allele is the lack of the TE insertion. C Normalized ChIP-Seq signal for E2F1 located at intron 1 of GTF2I (chr6:5,822,073–5,822,473 bp, padj = 0.03). D Expression of GTF2I exon 18 (padj = 0.138) as reported in the IGV track. E GTF2I exon-17—exon18 junction expression (padj = 0.141). Black circles show each data point, bar heights correspond to group means, and error bars correspond to standard errors