Fig. 1

PDGF-BB changes chromatin accessibility in MSC. (A) Volcano plot of ATAC-seq data from MSCs treated with and without PDGF-BB after 48 h. The pink dots correspond to increased accessibility upon PDGF-BB treatment. The blue dots correspond to decreased accessibility upon PDGF-BB treatment. (B) Examples of less accessible ATAC-seq open chromatin regions in PDGF-BB treated samples (green) compared with Control MSC samples (black). The y-axis represents normalized reads per million. (C) Examples of more accessible ATAC-seq open chromatin regions in PDGF-BB treated samples (green) compared with control MSC samples (black). The y-axis represents normalized reads per million. (D) Bar plots showing changes in the distribution of differential accessible regions in the genome. The numbers displayed in the bar plots represent the percentage of a genomic feature among all genomic features in all peaks, including more accessible regions and less accessible regions