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Fig. 2 | BMC Genomics

Fig. 2

From: Dynamic chromatin accessibility and transcriptome changes following PDGF-BB treatment of bone-marrow derived mesenchymal stem cells

Fig. 2

Differential analysis of RNA-seq data from PDGF-BB treated and control samples. (A) Volcano plot of RNA-seq from MSCs treated with and without PDGF-BB for 48 h. The pink dots and blue dots correspond to up-regulated genes and down-regulated genes respectively upon PDGF-BB treatment. (B) Functional analysis of up-regulated and down-regulated genes after PDGF-BB treatment. The numbers in the first column indicate the size of each hallmark gene set. The second and third columns present the count of differentially expressed genes that are up-regulated and down-regulated, respectively. These genes overlap with the hallmark gene sets, and the total number of genes is displayed at the top. Hallmark gene sets that are significantly overrepresented in up-regulated genes are marked in red (p < 0.01), and those in down-regulated genes are indicated in blue. (C) Overlap of differentially expressed genes with exosome related genes. Significant overlaps (p < 10− 3) were marked asterisk

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BMC Genomics

ISSN: 1471-2164

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