Table 2 Examples of differentially expressed genes (adjusted p < 0.05, fold change > 2) in fat bodies of bees exposed to heavy metals. Note that there were also two uncharacterized proteins upregulated and one downregulated (not shown in table but BIMP_3.0 gene identifiers available in Supplemental dataset 1)
Top upregulated genes (P < 0.05, FC > 2) |  | ||
|---|---|---|---|
BIMP_3.0 Gene Identifier | Putative gene name | Best hit from | Function |
BimpGene_00005435 | trypsin Blo t 3 | Bombus impatiens | digestive enzyme |
BimpGene_00013019 | titin | Apis florea | molecular spring muscle protein |
BimpGene_00006031 | G protein-coupled receptor kinase 5 isoform X2 | Bombus impatiens | serine/threonine protein kinase |
BimpGene_00005568 | homeotic protein empty spiracles-like | Bombus bifarius | developmental control of antennal and mandibular segment identity |
BimpGene_00010558 | flocculation protein FLO11-like | Megachile rotundata | adhesive cell-cell interactions |
BimpGene_00009799 | dynein heavy chain 7 | Bombus bifarius | motor proteins that aid sliding between ciliary doublet microtubules |
BimpGene_00008936 | serine protease hepsin | Cephus cinctus | regulation of glucose, lipid, and protein metabolism. |
BimpGene_00001758 | collagen alpha-1(I) chain | Bombus impatiens | major structural protein |
BimpGene_00013691 | N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase | Bombus impatiens | enzyme from the GPI biosynthetic pathway |
BimpGene_00013159 | protein lethal(2)essential for life | Bombus impatiens | heat shock protein |
Top downregulated genes (P < 0.05, FC > 2) |  | ||
BIMP_3.0 Gene Identifier | Putative gene name | Best hit from | Function |
BimpGene_00006095 | pupal cuticle protein-like | Bombus vosnesenskii | major structural protein of the cuticle |
BimpGene_00000672 | SCY1-like protein 2 isoform X1 | Bombus impatiens | clathrin-dependent trafficking at plasma membrane |
BimpGene_00002104 | feline leukemia virus subgroup C receptor-related protein 2-like isoform X1 | Bombus bifarius | virus receptor |
BimpGene_00000729 | bric-a-brac 2-like | Bombus impatiens | organ morphogenesis and regulation of stem cell differentiation |
BimpGene_00007889 | ras-like protein family member 10B | Eufriesea mexicana | enable G protein activity and GTP binding activity |