Fig. 6

A summary of the relationships of features, components, and aging-related risk factors. Features shown in the left column are those with absolute loadings higher than 0.1 on the corresponding component. Components are in the middle and the early-life aging risk factors are in the right column. Links between the features and components stand for the loadings. Links between the components and risk factors stand for the standardized associations which were identified as significant under Bonferroni correction. The association with the only risk factor, child body mass index (BMI) z-score (zBMI), was estimated in a multiple regression model adjusted for all the other risk factors (gestational age, birth weight, maternal pre-pregnancy BMI, maternal smoking status, maternal education level, parental smoking in the children’s household, family affluence score, child physical activity level and child Mediterranean diet score). MetS: serum metabolites. MetU: urinary metabolites. Prot: plasma proteins