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Fig. 3 | BMC Genomics

Fig. 3

From: Epidermal growth factor dampens pro-inflammatory gene expression induced by interferon-gamma in global transcriptome analysis of keratinocytes

Fig. 3

EGF expression associated with lower CXCL10, GBP5, MHC-class II and cytokine signaling pathway gene expression in psoriatic and matched normal skin. Gene expression Z-scores were calculated from RNA-seq data of skin biopsies collected from 116 individuals with psoriasis enrolled in the AMAGINE Phase III randomized clinical trials. Gene expression Z-scores of psoriatic lesions and matched normal (non-lesional) skin at low and high EGF expression tertile for (a-b) CXCL10, (c-d) GBP5, (e-f) combined expression of genes in cytokine signaling pathway (KEGG:04060), and (g-h) combined expression of genes in MHC-class II antigen presentation (GO:0019886). (Bonferroni-adjusted P-values: * < 0.05; ** < 0.01; *** <0.001; ****<0.0001)

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BMC Genomics

ISSN: 1471-2164

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