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Table 4 List of gene sets enriched for both cow conception rate at first service (CCR1) and the number of breeding services required for conception (TBRD)

From: Validation of loci and genes associated with fertility in Holstein cows using gene-set enrichment analysis-SNP and genotype-by-sequencing

Functional

Category

Gene seta

NES b

CCR1

TBRD

Cellular Component Organization

Actin cytoskeleton organization (GO:0030036)

3.055

3.32

Actin filament based process (GO:0030029)

3.101

3.245

Cellular component assembly (GO:0022607)

3.34

4.08

Cellular component biogenesis (GO:0044085)

3.261

3.626

Cellular localization (GO:0051641)

3.765

3.083

Cellular macromolecular complex assembly (GO:0065003)

4.055

3.434

Cellular macromolecule localization (GO:0070727)

3.031

3.146

Cellular protein complex assembly (GO:0065003)

3.932

3.35

Cytoskeleton organization (GO:0007010)

3.331

3.183

Gap junction (K - hsa04540)

3.966

3.5

Macromolecular complex assembly (GO:0065003)

4.472

3.967

Macromolecular complex binding (GO:0044877)

4.131

3.348

Macromolecular complex subunit organization (GO:0043933)

3.261

3.785

Macromolecule localization (GO:0033036)

3.051

3.057

Organelle localization (GO:0051640)

3.509

3.15

Protein complex assembly (GO:0065003)

4.384

3.633

Protein complex biogenesis (GO:0070271)

4.234

3.488

Mitotic Cell Cycle

Cell cycle (R-HSA-1640170)

4.869

3.414

Cell Cycle, Mitotic (R-HSA-69278)

5.077

3.831

Cell division (GO:0051301)

3.092

3.649

Loss of NLP from mitotic centrosomes (R-HSA-380259)

4.676

4.293

Mitotic G2-G2/M phases (R-HSA-453274)

4.744

3.523

Recruitment of mitotic centrosome proteins and complexes (R-HSA-380270)

4.769

4.327

RNA & mRNA Metabolic Processes

Regulation of mRNA metabolic process (GO:1903311)

3.423

3.318

Regulation of mRNA processing (GO:0050684)

3.411

3.222

Regulation of RNA splicing (GO:0043484)

4.311

4.062

Signaling Pathways

Neurotrophin signaling pathway (K - hsa04722)

3.749

3.293

Notch signaling pathway (P00045)

3.139

3.629

Signaling by NGF (R-HSA-187037)

4.423

3.208

Other

Cilium morphogenesis (GO:0060271)

4.236

3.237

Positive regulation of lipid biosynthetic process (GO:0046889)

3.281

3.112

Protein polymerization (GO:0051258)

4.806

3.422

Retinol metabolism (K - map00830)

3.503

3.537

Transmembrane transport of small molecules

(R-HSA-382551)

3.43

3.23

  1. a Accession code for each gene set is in parentheses: Reactome– R; Gene Ontology– GO; Protein Analysis Through Evolutionary Relationships– P; Kyoto Encyclopedia for Genes and Genomes - K. b Normalized enrichment score (NES) for each gene set for CCR1 and TBRD