Fig. 1

Phylogenetic analysis of S. mansoni venom allergen-like protein CAP domains. The updated phylogenetic tree supports an evolutionary split between two distinct branches of previously proposed group 1 and group 2 proteins. The relative branch lengths are indicated by the scale bar. Newly identified SmVALs within this study and SmVALs put in the phylogenetic analysis are marked with an asterisk. SmVALs containing signal peptides within the sequence according to Phobius analysis are in bold