Fig. 2

Multiple sequence alignment of 36 S. mansoni SCP/TAPS domains. Newly identified SmVALs within this study are in bold. The asterisk at SmVAL29 signifies that although identified before this study, it has been first time analysed. The black bar below the sequence alignment indicates CAP domain location. Highly conserved residues (≥ 90% identity threshold) are highlighted based on physicochemical properties (aliphatic/hydrophobic—pink, aromatic—orange, positive—blue, negative—red, hydrophilic—green, conformationally special—magenta). Conserved cysteine residues are highlighted in yellow. Distinct deletion regions typical for previously proposed group 1 and group 2 SmVALs are boxed. The alignment was processed in Jalview [35]