Assessing the association between ADH5 and ALDH1A1 genetic variants and substance use disorder risk in a Jordanian male population

Table 1 ADH5 and ALDH1A1 SNPs, their positions (GRCh38 genome build), minor allele frequencies among drug addiction patients and healthy controls, and HWEc P-values for the candidate gene polymorphisms

Gene	SNP-ID	SNP Position^a	Cases (n = 496)		Controls (n = 496)
Gene	SNP-ID	SNP Position^a	MA^b	MAF^c	MA^b	MAF^c	HWE^d P-value
*ADH5*	rs17595424	4:99072718	0	0.12	T	0.1	0.63
	rs1154414	4:99078985	C	0.16	C	0.15	0.86
	rs7683704	4:99083075	T	0.16	T	0.14	0.35
	rs7684986	4:99070525	T	0.11	T	0.1	0.3
	rs1154405	4:99087599	G	0.25	G	0.26	0.73
	rs1154401	4:99088587	G	0.33	G	0.33	0.84
	rs1154400	4:99088859	C	0.33	C	0.32	0.92
*ALDH1A1*	rs8187876	9:72950038	T	0.12	T	0.13	0.17
	rs1888202	9:72904335	G	0.44	G	0.93	0.93
	rs348457	9:72915638	G	0.47	G	0.49	0.15
	rs2773806	9:72936384	C	0.11	C	0.1	0.81
	rs1424482	9:72948641	C	0.41	C	0.45	0.32
	rs63319	9:72909868	G	0.47	G	0.45	0.09
	rs4745209	9:73025189	C	0.3	C	0.32	0.53
	rs6560311	9:72997266	T	0.32	T	0.36	0.09
	rs4406477	9:73037542	C	0.43	C	0.46	0.65
	rs11143443	9:73041134	C	0.03	C	0.02	1
	rs1364451	9:72993844	T	0.13	T	0.15	0.21
	rs1418187	9:73022744	A	0.32	A	0.33	0.48
	rs2249978	9:73012182	A	0.38	A	0.4	0.71

ISSN: 1471-2164