Table 3 Genetic association analysis of the polymorphisms in drug addiction cases and controls using different genetic models
Gene | SNP-ID | Model | Genotype | Cases (496 %) | Controls (496%) | OR (95% CI) | P-Value |
|---|---|---|---|---|---|---|---|
ADH5 | rs17595424 | Codominant | G/G G/T T/T | 381 (78.1%) 98 (19.9%) 9 (1.8%) | 398 (80.4%) 91 (18.4%) 6 (1.2%) | 1.00 0.90 (0.65-1.23) 0.64 (0.23-1.83) | 0.59 |
Dominant | G/G G/T-T/T | 385 (78.2%) 107 (21.8%) | 398 (80.4%) 97 (19.6%) | 1.00 0.88 (0.64-1.19) | 0.4 | ||
Recessive | G/G-G/T T/T | 483 (98.2%) 9 (1.8%) | 489 (98.8%) 6 (1.2%) | 1.00 0.66 (0.23-1.86) | 0.43 | ||
Over Dominant | G/G-T/T G/T | 394 (80.1%) 98 (19.9%) | 404 (81.6%) 91 (18.4%) | 1.00 0.91 (0.66-1.24) | 0.54 | ||
rs1154414 | Codominant | T/T C/T C/C | 340 (70.7%) 124 (25.8%) 17 (3.5%) | 349 (71.5%) 127 (26%) 12 (2.5%) | 1.00 1.00 (0.75-1.33) 0.69 (0.32-1.46) | 0.62 | |
Dominant | T/T C/T-C/C | 340 (70.7%) 141 (29.3%) | 349 (71.5%) 139 (28.5%) | 1.00 0.96 (0.73-1.27) | 0.78 | ||
Recessive | T/T-C/T C/C | 464 (96.5%) 17 (3.5%) | 476 (97.5%) 12 (2.5%) | 1.00 0.69 (0.33-1.46) | 0.32 | ||
Over Dominant | T/T-C/C C/T | 357 (74.2%) 124 (25.8%) | 361 (74%) 127 (26%) | 1.00 1.01 (0.76-1.35) | 0.93 | ||
rs7683704 | Codominant | C/C C/T T/T | 353 (71.9%) 122 (24.9%) 16 (3.3%) | 369 (74.5%) 114 (23%) 12 (2.4%) | 1.00 0.89 (0.67-1.20) 0.72 (0.33-1.54) | 0.55 | |
Dominant | C/C C/T-T/T | 353 (71.9%) 138 (28.1%) | 369 (74.5%) 126 (25.4%) | 1.00 0.87 (0.66-1.16) | 0.35 | ||
Recessive | C/C-C/T T/T | 457 (96.7%) 16 (3.3%) | 483 (97.6%) 12 (2.4%) | 1.00 0.74 (0.35-1.58) | 0.43 | ||
Over Dominant | C/C-T/T C/T | 369 (75.2%) 122 (24.9%) | 381 (77%) 114 (23%) | 1.00 0.90 (0.68-1.21) | 0.5 | ||
rs7684986 | Codominant | C/C C/T T/T | 378 (78.8%) 99 (20.6%) 3 (0.6%) | 391 (80.8%) 91 (18.8%) 2 (0.4%) | 1.00 0.89 (0.65-1.22) 0.64 (0.11-3.88) | 0.69 | |
Dominant | C/C C/T-T/T | 378 (78.8%) 102 (21.2%) | 391 (80.8%) 93 (19.2%) | 1.00 0.88 (0.64-1.21) | 0.43 | ||
Recessive | C/C-C/T T/T | 477 (99.4%) 3 (0.6%) | 482 (99.6%) 2 (0.4%) | 1.00 0.66 (0.11-3.97) | 0.65 | ||
Over Dominant | C/C-T/T C/T | 381 (79.4%) 99 (20.6%) | 393 (81.2%) 91 (18.8%) | 1.00 0.89 (0.65-1.22) | 0.48 | ||
rs1154405 | Codominant | A/A G/A G/G | 277 (56.3%) 182 (37%) 33 (6.7%) | 267 (54%) 195 (39.5%) 32 (6.5%) | 1.00 1.11 (0.85-1.45) 1.01 (0.60-1.68) | 0.72 | |
Dominant | A/A G/A-G/G | 277 (56.3%) 215 (43.7%) | 267 (54%) 227 (46%) | 1.00 1.10 (0.85-1.41) | 0.48 | ||
Recessive | A/A-G/A G/G | 459 (93.3%) 33 (6.7%)) | 462 (93.5%) 32 (6.5%) | 1.00 0.96 (0.58-1.59) | 0.88 | ||
Over Dominant | A/A-G/G G/A | 310 (63%) 182 (37%) | 299 (60.5%) 195 (39.5%) | 1.00 1.11 (0.86-1.44) | 0.42 | ||
rs1154401 | Codominant | C/C C/G G/G | 226 (46.1%) 207 (42.2%) 57 (11.6%) | 225 (45.5%) 215 (43.5%) 54 (10.9%) | 1.00 1.04 (0.80-1.36) 0.95 (0.63-1.44) | 0.9 | |
Dominant | C/C C/G-G/G | 226 (46.1%) 246 (53.9%) | 225 (45.5%) 269 (54.5%) | 1.00 1.02 (0.80-1.32) | 0.86 | ||
Recessive | C/C-C/G G/G | 433 (88.4%) 57 (11.6%) | 440 (89.1%) 54 (10.9%) | 1.00 0.93 (0.63-1.38) | 0.73 | ||
Over Dominant | C/C-G/G C/G | 283 (57.8%) 207 (42.2%) | 279 (56.5%) 215 (43.5%) | 1.00 1.05 (0.82-1.36) | 0.69 | ||
rs1154400 | Codominant | T/T C/T C/C | 228 (46.1%) 210 (42.5%) 56 (11.3%) | 227 (46%) 215 (43.5%) 52 (10.5%) | 1.00 1.03 (0.79-1.34) 0.93 (0.61-1.42) | 0.9 | |
Dominant | T/T C/T-C/C | 228 (46.1%) 266 (53.9%) | 227 (46%) 267 (54%) | 1.00 1.01 (0.79-1.29) | 0.95 | ||
Recessive | T/T-C/T C/C | 438 (88.7%) 56 (11.3%) | 442 (89.5%) 52 (10.5%) | 1.00 0.92 (0.62-1.37) | 0.68 | ||
Over Dominant | T/T-C/C C/T | 284 (57.5%) 210 (42.5%) | 279 (56.5%) 215 (43.5%) | 1.00 1.04 (0.81-1.34) | 0.75 | ||
ALDH1A1 | rs8187876 | Codominant | C/C C/T T/T | 388 (78.7%) 92 (18.7%) 13 (2.6%) | 376 (76.1%) 106 (21.5%) 12 (2.4%) | 1.00 1.19 (0.87-1.63) 0.95 (0.43-2.11) | 0.54 |
Dominant | C/C C/T-T/T | 388 (78.7%) 105 (21.3%) | 376 (76.1%) 118 (23.9%) | 1.00 1.16 (0.86-1.56) | 0.33 | ||
Recessive | C/C-C/T T/T | 480 (97.4% 13 (2.6%) | 482 (97.6%) 12 (2.4%) | 1.00 0.92 (0.42-2.04) | 0.84 | ||
Over Dominant | C/C-T/T C/T | 401 (81.3%) 92 (18.7%) | 388 (78.5%) 106 (21.5%) | 1.00 1.19 (0.87-1.63) | 0.27 | ||
rs1888202 | Codominant | C/C C/G G/G | 154 (31.4%) 244 (49.7%) 93 (18.9%) | 171 (34.7%) 238 (48.3%) 84 (17%) | 1.00 0.88 (0.66-1.16) 0.81 (0.56-1.17) | 0.49 | |
Dominant | C/C C/G-G/G | 154 (31.4%) 337 (68.6%) | 171 (34.7%) 322 (65.3%) | 1.00 0.86 (0.66-1.12) | 0.27 | ||
Recessive | C/C-C/G G/G | 398 (81.1%) 93 (18.9%) | 409 (83%) 84 (17%) | 1.00 0.88 (0.63-1.22) | 0.44 | ||
Over Dominant | C/C-G/G C/G | 247 (50.3%) 244 (49.7%) | 255 (51.7%) 238 (48.3%) | 1.00 0.94 (0.74-1.21) | 0.66 | ||
rs348457 | Codominant | C/C C/G G/G | 146 (30%) 226 (46.4%) 115 (23.6%) | 138 (27.9%) 231 (46.7%) 126 (25.4%) | 1.00 1.08 (0.80-1.45) 1.16 (0.82-1.63) | 0.7 | |
Dominant | C/C C/G-G/G | 146 (30%) 341 (70%) | 138 (27.9%) 357 (72.1%) | 1.00 1.11 (0.84-1.46) | 0.47 | ||
Recessive | C/C-C/G G/G | 372 (76.4%) 115 (23.6%) | 369 (74.5%) 126 (25.4%) | 1.00 1.10 (0.83-1.48) | 0.5 | ||
Over Dominant | C/C-G/G C/G | 261 (53.6%) 226 (46.4%) | 264 (53.3%) 231 (46.7%) | 1.00 1.01 (0.79-1.30) | 0.93 | ||
rs2773806 | Codominant | T/T C/T C/C | 396 (80.2%) 91 (18.4%) 7 (1.4%) | 397 (80.2%) 94 (19%) 4 (0.8%) | 1.00 1.03 (0.75-1.42) 0.57 (0.17-1.96) | 0.64 | |
Dominant | T/T C/T-C/C | 396 (80.2%) 98 (19.8%) | 397 (80.2%) 98 (19.8%) | 1.00 1.00 (0.73-1.36) | 0.99 | ||
Recessive | T/T-C/T C/C | 487 (98.6%) 7 (1.4%) | 497 (99.2%) 4 (0.8%) | 1.00 0.57 (0.16-1.95) | 0.36 | ||
Over Dominant | T/T-C/C C/T | 403 (81.6%) 91 (18.4%) | 401 (81%) 94 (19%) | 1.00 1.04 (0.75-1.43) | 0.82 | ||
rs1424482 | Codominant | T/T C/T C/C | 179 (36.5%) 220 (44.8%) 92 (18.7%) | 154 (31.1%) 234 (47.3%) 107 (21.6%) | 1.00 1.24 (0.93-1.64) 1.35 (0.95-1.92) | 0.18 | |
Dominant | T/T C/T-C/C | 179 (36.5%) 312 (63.5%) | 154 (31.1%) 341 (68.9%) | 1.00 1.27 (0.98-1.66) | 0.076 | ||
Recessive | T/T-C/T C/C | 399 (81.3%) 92 (18.7%) | 388 (78.4%) 107 (21.6%) | 1.00 1.20 (0.88-1.63) | 0.26 | ||
Over Dominant | T/T-C/C C/T | 271 (55.2%) 220 (44.8%) | 261 (52.7%) 234 (47.3%) | 1.00 1.10 (0.86-1.42) | 0.44 | ||
rs63319 | Codominant | T/T G/T G/G | 141 (29.8%) 219 (46.2%) 114 (24.1%) | 154 (32.3%) 218 (45.7%) 105 (22%) | 1.00 0.91 (0.68-1.22) 0.84 (0.59-1.20) | 0.63 | |
Dominant | T/T G/T-G/G | 141 (29.8%) 333 (70.2%) | 154 (32.3%) 323 (76.7%) | 1.00 0.89 (0.67-1.17) | 0.4 | ||
Recessive | T/T-G/T G/G | 360 (76%) 114 (24.1%) | 372 (78%) 105 (22%) | 1.00 0.89 (0.66-1.21) | 0.46 | ||
Over Dominant | T/T-G/G G/T | 255 (53.8%) 219 (46.2%) | 259 (54.3%) 218 (45.7%) | 1.00 0.98 (0.76-1.26) | 0.88 | ||
rs4745209 | Codominant | T/T C/T C/C | 245 (50.3%) 196 (40.2%) 46 (9.4%) | 223 (46.5%) 204 (42.5%) 53 (11%) | 1.00 1.14 (0.88-1.49) 1.27 (0.82-1.95) | 0.44 | |
Dominant | T/T C/T-C/C | 245 (50.3%) 242 (49.7%) | 223 (46.5%) 257 (53.5%) | 1.00 1.17 (0.91-1.50) | 0.23 | ||
Recessive | T/T-C/T C/C | 441 (90.5%) 46 (9.4%) | 427 (89%) 53 (11%) | 1.00 1.19 (0.78-1.81) | 0.41 | ||
Over Dominant | T/T-C/C C/T | 291 (59.8%) 196 (40.2%) | 276 (57.5%) 204 (42.5%) | 1.00 1.10 (0.85-1.42) | 0.48 | ||
rs6560311 | Codominant | G/G G/T T/T | 231 (47.1%) 200 (40.8%) 59 (12%) | 209 (43.2%) 205 (42.4%) 70 (14.5%) | 1.00 1.13 (0.86-1.48) 1.31 (0.88-1.94) | 0.36 | |
Dominant | G/G G/T-T/T | 231 (47.1%) 259 (52.9%) | 209 (43.2%) 275 (56.8%) | 1.00 1.17 (0.91-1.51) | 0.21 | ||
Recessive | G/G-G/T T/T | 431 (88%) 59 (12%) | 414 (85.5%) 70 (14.5%) | 1.00 1.24 (0.85-1.79) | 0.26 | ||
Over Dominant | G/G-T/T G/T | 290 (59.2%) 200 (40.8%) | 279 (57.6%) 205 (42.4%) | 1.00 1.07 (0.83-1.37) | 0.63 | ||
rs4406477 | Codominant | T/T C/T C/C | 173 (35.7%) 208 (42.9%) 104 (21.4%) | 148 (30.2%) 238 (48.6%) 104 (21.2%) | 1.00 1.34 (1.00-1.78) 1.17 (0.82-1.66) | 0.14 | |
Dominant | T/T C/T-C/C | 173 (35.7%) 312 (64.3%) | 148 (30.2%) 342 (69.8%) | 1.00 1.28 (0.98-1.67) | 0.07 | ||
Recessive | T/T-C/T C/C | 381 (78.6%) 104 (21.4%) | 386 (78.8%) 104 (21.2%) | 1.00 0.99 (0.73-1.34) | 0.93 | ||
Over Dominant | T/T-C/C C/T | 277 (57.1%) 208 (42.9%) | 252 (51.4%) 238 (48.6%) | 1.00 1.26 (0.98-1.62) | 0.08 | ||
rs11143443 | Codominant | T/T C/T CC | 464 (93.9%) 29 (5.9%) 1 (0.2%) | 473 (95.8%) 21 (4.2%) 0 (0%) | 1.00 0.71 (0.40-1.26) NA (0.00-NA) | 0.25 | |
Dominant | T/T C/T-C/C | 464 (93.9%) 30 (6.1%) | 473 (95.8%) 21 (4.2%) | 1.00 0.69 (0.39-1.22) | 0.19 | ||
Recessive | T/T-C/T C/C | 493 (99.8%) 1 (0.2%) | 494 (100%) 0 (0%) | 1.00 NA (0.0-NA) | 0.24 | ||
Over Dominant | T/T-C/C C/T | 465 (94.1%) 29 (5.9%) | 473 (95.8%) 21 (4.2%) | 1.00 0.71 (0.40-1.27) | 0.24 | ||
rs1364451 | Codominant | C/C T/C T/T | 377 (76.6%) 105 (21.3%) 10 (2%) | 360 (72.9%) 119 (24.1%) 15 (3%) | 1.00 1.19 (0.88-1.60) 1.57 (0.70-3.54) | 0.32 | |
Dominant | C/C T/C-T/T | 377 (76.6%) 115 (23.4%) | 360 (72.9%) 134 (27.1%) | 1.00 1.22 (0.91-1.63) | 0.18 | ||
Recessive | C/C-T/C T/T | 478 (98%) 10 (2%) | 475 (96.9%) 15 (3%) | 1.00 1.51 (0.67-3.39) | 0.31 | ||
Over Dominant | C/C-T/T T/C | 387 (78.9%) 105 (21.3%) | 375 (75.9%) 119 (24.1%) | 1.00 1.17 (0.87-1.58) | 0.27 | ||
rs1418187 | Codominant | G/G G/A A/A | 231 (46.8%) 208 (42.1%) 55 (11.1%) | 223 (45%) 214 (43.2%) 58 (11.7%) | 1.00 1.07 (0.82-1.39) 1.09 (0.72-1.65) | 0.86 | |
Dominant | G/G G/A-A/A | 231 (46.8%) 263 (53.2%) | 223 (45%) 272 (55%) | 1.00 1.07 (0.83-1.38) | 0.59 | ||
Recessive | G/G-G/A A/A | 439 (88.9%) 55 (11.1%) | 437 (88.3%) 58 (11.7%) | 1.00 0.92 (0.62-1.37) | 0.77 | ||
Over Dominant | G/G-A/A G/A | 286 (57.9%) 208 (42.1%) | 281 (56.8%) 214 (43.2%) | 1.00 0.99 (0.77-1.27) | 0.72 | ||
rs2249978 | Codominant | G/G G/A A/A | 196 (40.6%) 209 (43.3%) 78 (16.1%) | 177 (36.3%) 230 (47.2%) 80 (16.4%) | 1.00 0.82 (0.62-1.08) 0.88 (0.61-1.28) | 0.37 | |
Dominant | G/G G/A-A/A | 196 (40.6%) 287 (59.4%) | 177 (36.3%) 310 (63.7%) | 1.00 0.84 (0.65-1.08) | 0.18 | ||
Recessive | G/G-G/A A/A | 405 (83.8%) 78 (16.1%) | 407 (83.6%) 80 (16.4%) | 1.00 0.98 (0.70-1.38) | 0.91 | ||
Over Dominant | G/G-A/A G/A | 274 (56.7%) 209 (43.3%) | 257 (52.8%) 230 (47.2%) | 1.00 0.85 (0.66-1.10) | 0.22 |