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Fig. 7 | BMC Genomics

Fig. 7

From: Chromatin remodeling protein BPTF mediates chromatin accessibility at gene promoters in planarian stem cells

Fig. 7

Model of BPTF/NuRF function in planarian stem cells. A) SMED-BPTF is predicted to bind histone H3 lysine 4 trimethylation (H3K4me3; orange circles), recruiting the rest of the NuRF complex and its ATP-dependent chromatin remodeling activity to transcription start sites. Many other genes in the planarian genome are not marked by H3K4me3, but do have BPTF-dependent regions of chromatin accessibility. It is possible that other chromatin modifications, such as acetylation (magenta triangles), are responsible for recruiting and/or stabilizing BPTF/NuRF. B) Genes marked by Set1-dependent H3K4me3 have more open chromatin and higher expression than those marked by MLL1/2-dependent H3K4me3

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BMC Genomics

ISSN: 1471-2164

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