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Fig. 4 | BMC Genomics

Fig. 4

From: Multi-omic latent variable data integration reveals multicellular structure pathways associated with resistance to tuberculin skin test (TST)/interferon gamma release assay (IGRA) conversion in Uganda

Fig. 4

Expression of IFNγ-related genes is greater in TBI than RSTR. Features in the Factor 1 reduced MOFA feature list belonging to the GO IFNγ production pathway are shown, in addition to IFNγ itself. IFNγ and NLRP6 are represented in the reduced feature list as part of the the Mtb-stimulated RNAseq dataset. KLRK1 is contributed by the both the Mtb-stimulated and media-only RNA-seq datasets, and CD2, CD3E, CD96, and GATA3 are contributed by the media-only RNA-seq dataset. For all features in both datasets, expression in greater in TBI than RSTR (FDR < 0.1). Group differences tested by ANOVA; black squares represent groupwise means

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BMC Genomics

ISSN: 1471-2164

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