Table 3 Summary of select high-weight MOFA features with high loadings on latent variables generated in at least two out of three alternative data integration methods
MOFA factor | Dataset (% variance explained on factor) | Number of select MOFA features | Number of features also identified in 2/3 non-MOFA methods (%) | Number of unique protein coding HGNC symbols |
|---|---|---|---|---|
Factor 1 | RNA Mtb (50%) | 177 | 41 (23%) | 40 |
RNA media (48%) | 169 | 84 (50%) | 83 | |
Total (98%) | 346 | 113 (32%) | 111 | |
Factor 2 | ATAC-seq (98%) | 605 | 132 (22%) | 94 |
Factor 3 | Methylation (91%) | 1198 | 372 (31%) | 345 |
SNP (6%) | 94 | 77 (82%) | 35 | |
Total (97%) | 1292 | 449 (35%) | 379 | |
Factor 4 | SNP (59%) | 973 | 334 (34%) | 173 |
Methylation (19%) | 249 | 114 (46%) | 106 | |
RNA Mtb (11%) | 40 | 22 (55%) | 20 | |
ATAC-seq (7%) | 41 | 13 (32%) | 11 | |
Total (96%) | 1303 | 483 (37%) | 307 |