Table 1 Evolutionary conservation of highly constrained sORFs neighbored by genes with associated phenotypes
sORF | Gene | Mean phyloP sORF | Mean phyloP gene | sORF class | Conservation status established by Sandmann et al. [17] |
|---|---|---|---|---|---|
C9NOREP73 | AOPEP | 0.11 | 2.62 | dORF | Primatomorpha |
C18NOREP74 | BCL2 | 2.52 | 1.60 | uORF | Human |
C20NOREP99 | EEF1A2 | 4.11 | 3.98 | dORF | Primatomorpha |
C5RIBOSEQORF120 | ERGIC1 | 1.14 | 2.25 | dORF | Old work Monkeys |
C8RIBOSEQORF34 | EXTL3 | 1.25 | 1.66 | uORF | Primatomorpha |
CXRIBOSEQORF28 | FGD1 | 2.82 | 3.28 | uORF | Primatomorpha |
CXNOREP99 | FGF13 | 2.92 | 0.38 | uORF | Primatomorpha |
C19NOREP210 | FUT1 | -0.46 | 0.63 | uORF | Primatomorpha |
C4RIBOSEQORF123 | HAND2 | 2.82 | 3.19 | uORF | Conserved |
C1RIBOSEQORF39 | HNRNPR | 6.02 | 3.01 | intORF | Conserved |
CXRIBOSEQORF37 | IGBP1 | -0.52 | 1.68 | uORF | Primatomorpha |
CXNOREP24 | KDM6A | 4.85 | 3.71 | intORF | Conserved |
C17RIBOSEQORF80 | KRT10 | 2.78 | 2.88 | dORF | Primatomorpha |
C19NOREP118 | LSM14A | 5.17 | 3.55 | intORF | Conserved |
C5NOREP142 | MATR3 | 5.66 | 3.86 | intORF | Conserved |
CXRIBOSEQORF6 | MID1 | 3.71 | 1.68 | uORF | Conserved |
C16RIBOSEQORF112 | MTSS2 | 2.96 | 2.59 | uORF | Primatomorpha |
C1NOREP188 | NOTCH2 | 3.92 | 2.79 | intORF | Conserved |
C13NOREP28 | NUDT15 | 0.56 | 1.11 | dORF | Primatomorpha |
C5NOREP99 | PPIP5K2 | 2.12 | 1.38 | uORF | Primatomorpha |
C7NOREP21 | RAC1 | 4.94 | 2.89 | intORF | Primatomorpha |
CXRIBOSEQORF13 | SH3KBP1 | 2.96 | 2.76 | uORF | Conserved |
C16NOREP74 | SIAH1 | 5.48 | 3.92 | intORF | Conserved |
C8RIBOSEQORF45 | SLC20A2 | 4.18 | 2.71 | uORF | Primatomorpha |
CXNOREP28 | SYN1 | 0.99 | 3.37 | dORF | Primatomorpha |
C20NOREP24 | TASP1 | 5.06 | 3.81 | intORF | Old work Monkeys |
C3NOREP214 | TBL1XR1 | 6.23 | 3.50 | intORF | Conserved |
CXNOREP58 | TIMM8A | 2.24 | 2.08 | dORF | Primatomorpha |
CXNOREP11 | TMSB4X | 2.29 | 2.95 | dORF | Primatomorpha |
CXNOREP17 | ZFX | 3.98 | 1.98 | intORF | Conserved |