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Fig. 1 | BMC Genomics

Fig. 1

From: Identifying cross-tissue molecular targets of lung function by multi-omics integration analysis from DNA methylation and gene expression of diverse human tissues

Fig. 1

Study design of this work. FEV1: Forced expiratory volume in one second; FVC: Forced vital capacity; FEV1/FVC: Forced expiratory volume in one second and forced vital capacity ratio; QTL: Quantitative trait loci; GWAS: Genome-wide association study; GTEx: Genotype-Tissue Expression; SMR: Summary data-based Mendelian randomization; COLOC: Bayesian colocalization; MOLOC: Multiple-trait-coloc; HyPrColoc: Hypothesis Prioritisation for multi-trait Colocalization; FUMA: Functional mapping and annotation of genetic associations; FDR: False discover rate; HEIDI: Heterogeneity in dependent instrument; PPH4: Posterior probability of hypothesis 4; PPA: An overall posterior probability; PPMT: Posterior probability of multiple traits

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BMC Genomics

ISSN: 1471-2164

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