Fig. 2

Impact of TADs on regulation of transcriptional activity. (a) An overview of functional regulatory elements in Topologically Associated Domains (TADs) and their flanking regions. (b) Within TADs, TAD flanking regions, and the combined regions, enrichment analysis of Loss-of-Function variants (LoFs) (c), chromatin states (d), and eQTL and sQTL (e), the top 1% of predict effect score based on deep learning and ATAC-seq of 13 tissues. The distribution of each type of data in the combined TAD and flanking regions is shown in the right panel, with red, yellow, and green lines representing liver, adipose, and muscle tissues, respectively. Black lines indicate the three types of tissues