Table 3 Top down- and upregulated genes (comparison regression - re versus development/maintenance - dm). Here only genes are listed with have for the down-regulated genes values > 0 for all dm-samples and genes values > 0 for up-regulated genes in all re-samples
down = high in dm | up = high in re | ||||
|---|---|---|---|---|---|
gene name abbreviation | full gene name | fold change | gene name abbreviation | full gene name | fold change |
PENK | proenkephalin | -862.7 | ENSFCAG00000024877 | BRICK1 subunit of SCAR/WAVE actin nucleating complex | 833.8 |
CLDN4 | claudin 4 | -606.0 | FBXL16 | F-box and leucine rich repeat protein 16 | 644.0 |
OXT | oxytocin/neurophysin I prepropeptide | -304.9 | SERPINB3 | serpin family B member 3 | 549.1 |
ENSFCAG00000030530 | Elongation factor 1-alpha (UniProt match for transcript) | -300.9 | CYP26A1 | cytochrome P450 family 26 subfamily A member 1 | 392.2 |
ENSFCAG00000041846 | “LncRNA, no protein” | -299.0 | IL23R | interleukin 23 receptor | 213.5 |
ARG1 | arginase 1 | -273.4 | LOC101097497 | keratin, type II cytoskeletal 5-like | 196.9 |
AMTN | amelotin | -268.3 | IL13 | interleukin 13 | 184.7 |
APELA | apelin receptor early endogenous ligand | -267.0 | CCL13 | C-C motif chemokine ligand 13 | 179.3 |
SEC14L4 | Section 14 like lipid binding 4 | -263.6 | CILP2 | cartilage intermediate layer protein 2 | 165.5 |
PLA2G3 | phospholipase A2 group III | -252.5 | SERPIND1 | serpin family D member 1 | 155.3 |
ENSFCAG00000049737 | Cathepsin propeptide inhibitor domain-containing protein (UniProt match for transcript) | -225.7 | PPP1R17 | protein phosphatase 1 regulatory subunit 17 | 151.0 |
HSD3B1, HSD3B2 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 | -169.1 | PGLYRP2 | peptidoglycan recognition protein 2 | 150.9 |
SLC5A1 | solute carrier family 5 member 1 | -162.5 | CYP21A2 | cytochrome P450 family 21 subfamily A member 2 | 145.2 |
ENSFCAG00000042967 | “LncRNA, no protein” | -153.0 | INSRR | insulin receptor related receptor | 129.0 |
CNTN6 | contactin 6 | -140.6 | AKR1D1 | aldo-keto reductase family 1 member D1 | 117.9 |
FGA | fibrinogen alpha chain | -136.4 | ENSFCAG00000040543 | “LncRNA, no protein” | 114.1 |
FABP6 | fatty acid binding protein 6 | -133.9 | COL6A5 | collagen type VI alpha 5 chain | 112.5 |
RHCG | Rh family C glycoprotein | -133.6 | PGAM2 | phosphoglycerate mutase 2 | 112.1 |
LOC102902015 | probable inactive serine protease 58 | -133.3 | SLC29A4 | solute carrier family 29 member 4 | 102.1 |
PDC | phosducin | -131.3 | TMEM213 | transmembrane protein 213 | 101.9 |
GJE1 | gap junction protein epsilon 1 | -130.4 | NAGS | N-acetylglutamate synthase | 101.5 |
FGB | fibrinogen beta chain | -128.3 | PTPRT | protein tyrosine phosphatase receptor type T | 89.2 |
HSD17B3 | hydroxysteroid 17-beta dehydrogenase 3 | -126.7 | ENSFCAG00000048400 | “LncRNA, no protein” | 77.8 |
DLK1 | delta like non-canonical Notch ligand 1 | -103.0 | ENSFCAG00000051755 | “LncRNA, no protein” | 77.2 |
SERPINA3 | serpin family A member 3 | -102.4 | TGFBI | transforming growth factor beta induced | 75.8 |
IDO2 | indoleamine 2,3-dioxygenase 2 | -98.9 | ATP6V0A4 | ATPase H + transporting V0 subunit a4 | 75.5 |
FBP2 | fructose-bisphosphatase 2 | -96.2 | LYPD6 | LY6/PLAUR domain containing 6 | 73.3 |
ENSFCAG00000047393 | “Uncharacterized protein” | -95.1 | B3GALT2 | beta-1,3-galactosyltransferase 2 | 73.0 |
ENSFCAG00000043251 | “LncRNA, no protein” | -93.0 | NTRK1 | neurotrophic receptor tyrosine kinase 1 | 71.5 |
LHCGR | luteinizing hormone/choriogonadotropin receptor | -85.6 | SLC4A8 | solute carrier family 4 member 8 | 70.0 |
HAO2 | hydroxyacid oxidase 2 | -85.4 | LOC101080976 | pregnancy zone protein-like | 68.6 |
PLPPR1 | phospholipid phosphatase related 1 | -84.1 | TAS1R1 | taste 1 receptor member 1 | 65.3 |
CPHL1 | ceruloplasmin and hephaestin like 1 | -83.6 | MLXIPL | MLX interacting protein like | 64.3 |
AREG | amphiregulin | -83.1 | PERM1 | PPARGC1 and ESRR induced regulator, muscle 1 | 56.8 |
UNC13C | unc-13 homolog C | -81.2 | LEF1 | lymphoid enhancer binding factor 1 | 55.4 |
ASIC2 | acid sensing ion channel subunit 2 | -81.2 | CLEC4G | C-type lectin domain family 4 member G | 49.8 |
SULT1C3 | sulfotransferase family 1 C member 3 | -79.2 | RSPO4 | R-spondin 4 | 48.7 |
SUCNR1 | succinate receptor 1 | -69.9 | RHBG | Rh family B glycoprotein | 48.5 |
“novel gene” | “LncRNA, no protein” | -69.4 | ADIPOQ | adiponectin, C1Q and collagen domain containing | 48.3 |
CPB1 | carboxypeptidase B1 | -63.7 | BLK | BLK proto-onco, Src family tyrosine kinase | 46.5 |
PAQR5 | progestin and adipoQ receptor family member 5 | -58.9 | SLC6A4 | solute carrier family 6 member 4 | 46.4 |
CRHBP | corticotropin releasing hormone binding protein | -58.2 | FBXL21 | F-box and leucine rich repeat protein 21 | 45.8 |
ADGRG7 | adhesion G protein-coupled receptor G7 | -54.5 | INSYN2A | inhibitory synaptic factor 2 A | 45.1 |
“novel gene” | “LncRNA, no protein” | -54.4 | MME | membrane metalloendopeptidase | 43.6 |
CPNE9 | copine family member 9 | -52.9 | KCNK5 | potassium two pore domain channel subfamily K member 5 | 40.8 |
ATP1A3 | ATPase Na+/K + transporting subunit alpha 3 | -51.6 | CAPN13 | calpain 13 | 40.2 |
TMPRSS7 | transmembrane serine protease 7 | -51.4 | SVOPL | SVOP like | 37.9 |
GAL3ST1 | galactose-3-O-sulfotransferase 1 | -49.7 | TMEM221 | transmembrane protein 221 | 37.1 |
“novel gene” | “LncRNA, no protein” | -49.5 | NR4A2 | nuclear receptor subfamily 4 group A member 2 | 36.5 |
SLCO5A1 | solute carrier organic anion transporter family member 5A1 | -49.3 | ENSFCAG00000053105 | “LncRNA, no protein” | 36.4 |