RNA-sequencing demonstrates transcriptional differences between human vocal fold fibroblasts and myofibroblasts

BMC Genomics

Table 1 Gene ontology (GO) enrichment terms for the top 150 differentially expressed (DE) genes in each experimental group identified by RNA sequencing

	GO Term	Adj. p-value
Upregulated tVFF (red)
	Collagen binding	0.000284
	Growth factor activity	0.01705
	Integrin binding	0.021286
Upregulated cVFF and nVFF (green)
	Cell-cell adhesion mediator activity	0.021412
	Protein binding involved in heterotypic cell-cell adhesion	0.021412
	Cell adhesion mediator activity	0.021412
Upregulated sVFF (blue)
	Cytokine binding	0.0000194
	Receptor ligand activity	0.0000194
	Signaling receptor regulator activity	0.0000194
	Signaling receptor activator activity	0.00002
	Cytokine activity	0.0000611
	Glycosaminoglycan binding	0.001426
	Growth factor binding	0.004188
	Heparin binding	0.011846
	Scavenger receptor activity	0.013609
	Cargo receptor activity	0.023011
	Chemokine activity	0.030604
	Low-density lipoprotein particle receptor activity	0.040542

Cluster color (red, green, and blue) refers to colored hierarchical clusters across the top panel found in Fig. 3B. Adjusted P < 0.05

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