Table 2 This table summarizes the gene ontology (GO) biological process terms for 12 genes implicated in the immune response to viral infections, as identified through the MyGeneInfo API

OAS1

Glucose metabolic process, response to virus, positive regulation of interferon-beta production, positive regulation of tumor necrosis factor production, toll-like receptor 3 signaling pathway, toll-like receptor 4 signaling pathway, cellular response to interferon-alpha, cellular response to interferon-beta, glucose homeostasis, defense response to bacterium, surfactant homeostasis, negative regulation of viral genome replication, protein complex oligomerization, defense response to virus, type I interferon-mediated signaling pathway, negative regulation of type I interferon-mediated signaling pathway, regulation of ribonuclease activity, interleukin-27-mediated signaling pathway, positive regulation of monocyte chemotactic protein-1 production, negative regulation of IP-10 production, cellular response to virus, antiviral innate immune response, positive regulation of cellular respiration, negative regulation of chemokine (C-X-C motif) ligand 2 production.

IFIT2

Apoptotic mitochondrial changes, response to viruses, negative regulation of protein binding, positive regulation of apoptotic processes, defense against viruses, antiviral innate immune response.

IFI44

Immune response, response to viruses, response to bacterium

IFI27

Negative regulation of transcription by RNA polymerase II, release of cytochrome c from mitochondria, apoptotic processes, proteasome-mediated ubiquitin-dependent protein catabolic process, modulation by host of viral genome replication, innate immune responses, regulation of protein export from nucleus, various signaling pathways linked to the immune system.

IFIT3

Negative regulation of cell population proliferation, response to viruses, negative regulation of apoptotic process, defense against viruses, antiviral innate immune response.

IFI44L

Immune response, defense against viruses.

MX1

Apoptotic process, defense response, signal transduction, response to type I interferon, negative regulation of viral genome replication, innate immune responses, defense against viruses, interleukin-27-mediated signaling pathways.

MX2

Defense response, protein transport, response to interferon-alpha, innate immune response, regulation of nucleocytoplasmic transport, mRNA transport, regulation of the cell cycle.

OAS2

Nucleobase-containing compound metabolic process, RNA catabolic process, response to viruses, positive regulation of interferon-beta production, defense responses to bacteria, negative regulation of viral genome replication, type I interferon-mediated signaling pathways.

RSAD2

Response to viruses, positive regulation of toll-like receptor signaling pathways, T cell activation and differentiation, negative regulation of viral genome replication, innate immune responses, negative regulation of protein secretion, positive regulation of immune responses, defense responses to viruses.

OASL

Response to virus, negative regulation of viral genome replication, innate immune response, defense response to virus, type I interferon-mediated signaling pathway, interleukin-27-mediated signaling pathway, antiviral innate immune response, positive regulation of RIG-I signaling pathway.

ISG15

Integrin-mediated signaling pathway, response to viruses, protein ubiquitination, modification-dependent protein catabolic process, positive regulation of bone mineralization, negative regulation of protein ubiquitination, ISG15-protein conjugation, regulation of type II interferon production, positive regulation of interferon-beta production, interleukin production, response to type I interferon, defense against bacteria, innate immune responses, various other processes linked to cellular functions and immune modulation.