Skip to main content

Table 1 Top 10 enriched pathways within each predicted protein functional cluster

From: From unipotency to pluripotency: deciphering protein networks and signaling pathways in the generation of embryonic stem-like cells from murine spermatogonial stem cells

1st Cluster

Enriched Pathways

false discovery rate

strength

miRNAs and TFs in iPS Cell Generation

0.0021

2.47

GDNF/RET signaling axis

0.0095

1.98

Negative regulation of miRNA transcription

0.0189

1.94

DNA methylation

7.62E-05

1.89

Stem cell division

0.0293

1.81

Stem cell population maintenance

8.70E-05

1.54

Response to retinoic acid

0.00088

1.54

Mechanisms associated with pluripotency

6.87E-10

1.51

Wnt signaling pathway and pluripotency

0.0058

1.51

Signaling pathways regulating pluripotency of stem cells

0.0031

1.48

2nd Cluster

Enriched Pathways

false discovery rate

strength

Activation of NIMA Kinases NEK9, NEK6, NEK7

0.00088

2.74

Phosphorylation of Emi1

0.0011

2.66

PTK6 Regulates Cell Cycle

0.0011

2.66

TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest

0.0022

2.44

Phosphorylation of the APC/C

0.0072

2.14

Positive regulation of reactive oxygen species biosynthetic process

0.0264

2.06

Cyclin A/B1/B2 associated events during G2/M transition

0.0094

2.06

HDMs demethylate histones

0.0095

2.04

Type II interferon signaling (IFNG)

0.013

1.94

FLT3 Signaling

0.0141

1.93

3rd Cluster

Enriched Pathways

false discovery rate

strength

MET activates PTK2 signaling

0.013

2.24

Assembly of collagen fibrils and other multimeric structures

1.17E-05

2.18

Collagen degradation

1.31E-05

2.12

Matrix metalloproteinases

0.0052

2.11

Positive regulation of collagen biosynthetic process

0.0215

2.06

Non-integrin membrane-ECM interactions

0.0258

2.06

Activation of Matrix Metalloproteinases

0.0258

2.02

Collagen fibril organization

0.0024

2

Integrin cell surface interactions

2.90E-05

2

Collagen chain trimerization

0.0258

2

4th Cluster

Enriched Pathways

false discovery rate

strength

FGFRL1 modulation of FGFR1 signaling

0.000031

2.38

Phospholipase C-mediated cascade; FGFR2

0.000000853

2.36

FGFR2b ligand binding and activation

0.0023

2.36

FGFR2 ligand binding and activation

0.000000924

2.34

FGFR1 ligand binding and activation

0.0000415

2.32

Phospholipase C-mediated cascade: FGFR1

0.0000473

2.29

FGFR1c ligand binding and activation

0.0032

2.28

PI-3K cascade:FGFR2

0.00000166

2.26

SHC-mediated cascade:FGFR2

0.00000166

2.26

FRS-mediated FGFR2 signaling

0.0000019

2.22

Back to article page

BMC Genomics

ISSN: 1471-2164

Contact us