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Fig. 3 | BMC Genomics

Fig. 3

From: Single-cell multi-omics delineates the dynamics of distinct epigenetic codes coordinating mouse gastrulation

Fig. 3

Regulatory trajectory analysis of epiblast differentiation according to H3K27ac and H3K4me1 ChIP-seq signals. A: Force-directed graph (FDG) showing the differentiation trajectories of H3K27ac single cells from Fig. 1B. B: Partition-based approximate graph abstraction (PAGA) showing pseudotime trajectories of cells from (A). The size of the dots represents the relative number of cells in each cluster. C: FDG showing the differentiation trajectories of H3K4me1 single cells from Fig. 1C. D: PAGA showing pseudotime trajectories of cells from (C). The size of the dots represents the relative number of cells in each cluster. E and F: Heatmap (the upper panel) and line plot (the lower panel) showing the H3K27ac (E) and H3K4me1 (F) signals around lineage-specific genes along three lineage specifications in (A and C)

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BMC Genomics

ISSN: 1471-2164

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