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Fig. 3 | BMC Genomics

Fig. 3

From: Contrastive sequence signatures between the both sides of a recombination spot reveal an adaptation at PPARD locus from standing variation for pleiotropy since out-of-Africa dispersal

Fig. 3

Selection test and evolutionary inference of PPARD from a genealogy-based framework. a The regional plots of the selection tests in the combined Han Chinese of CHB and CHS, CEU and YRI populations using Relate. The most significant SNPs in each population are marked. b The extracted local trees for the SNPs of interest. The left part indicates the local tree for the top hit rs9470007 in CHB + CHS, and the right indicates the local tree for the top hit rs3777744 in CEU. The branches carrying the ancestral or derived allele are charted in different colors. c The approximate full-likelihood inferences of selection for the SNPs of interest using CLUES. The frequency trajectories of the selected alleles were inferred after resampling the genealogies of interest, and the log-likelihood ratios (LogLR) between selection and neutrality and the selection coefficients (s) were computed. The allele frequency trajectories are plotted against time in generations before the present

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BMC Genomics

ISSN: 1471-2164

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