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Fig. 5 | BMC Genomics

Fig. 5

From: Contrastive sequence signatures between the both sides of a recombination spot reveal an adaptation at PPARD locus from standing variation for pleiotropy since out-of-Africa dispersal

Fig. 5

Colocalization analysis between 109 GWAS traits and the eQTLs from whole blood. The prior parameters p1 = 10− 4, p2 = 10− 4, p12 = 5 × 10− 6 were adopted in the coloc.abf function for colocalization. a The clustered heatmap of the colocalized posterior probabilities of PP.H4.abf between the traits and the eQTLs. Heatmap colors correspond to PP.H4.abf values. The GWAS traits are arranged in rows, and the eGenes are in columns. The trait categorization is identical to that in the Phewas analyses. b The posterior probabilities of the most likely causal variants from colocalizing between each eGene and the GWAS traits. Each diamond stands for a variant with the highest posterior probability in each colocalization analysis. The prioritized variants are denoted in different colors

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BMC Genomics

ISSN: 1471-2164

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