Table 4 Results of protein stability changes due to the nucleotide polymorphisms predicted by MU Pro, I-Mutant2.0, and INPS3D
From: In-silico analysis of deleterious non-synonymous SNPs in the human AVPR1a gene linked to autism
Variant ID | Nucleotides | AA Variations | MU Pro | Score | I-Mutant2.0 | Score | INPS3D | Score |
|---|---|---|---|---|---|---|---|---|
rs1260022270 | C/T | R85H | Decrease | −1.0977846 | Decrease | 8 | Decrease | −0.229538 |
rs1267958616 | C/T | D202 N | Decrease | −0.43786389 | Decrease | 5 | Decrease | −0.497514 |
rs1321994497 | T/C | E54G | Decrease | −1.6185617 | Decrease | 9 | Decrease | −0.792783 |
rs1325662981 | T/G | H92P | Decrease | −0.88200575 | Increase | 6 | Decrease | −1.14777 |
rs1337643184 | C/A | D148Y | Decrease | −0.95038532 | Decrease | 3 | Decrease | −0.1177 |
rs1338176647 | A/C | C203G | Decrease | −1.9037191 | Decrease | 8 | Decrease | −3.26869 |
rs1369668995 | C/T | V297M | Decrease | −0.60384266 | Decrease | 8 | Decrease | −0.434777 |
rs1377891669 | T/A | D148 V | Decrease | −0.88691156 | Decrease | 2 | Increase | 1.16615 |
rs1417441306 | C/T | S182 N | Decrease | −0.32708786 | Increase | 3 | Decrease | −0.452437 |
rs1424280726 | T/A | Q108L | Increase | 0.36395533 | Increase | 2 | Increase | 0.0731143 |
rs1440280008 | G/A | R149 C | Decrease | −0.54728157 | Decrease | 6 | Decrease | −0.0546847 |
rs1449556252 | C/A | G212 V | Decrease | −0.39457627 | Decrease | 6 | Decrease | −0.851292 |
rs369710823 | A/G | M145 T | Decrease | −2.6523221 | Decrease | 8 | Decrease | −1.91913 |
rs376518166 | C/T | G212S | Decrease | −0.92599754 | Decrease | 9 | Decrease | −0.119486 |
rs745458336 | T/G | Y140S | Decrease | −1.845721 | Decrease | 6 | Decrease | −1.85495 |
rs748572296 | A/C | F207 V | Decrease | −0.82949321 | Decrease | 8 | Decrease | −1.16988 |
rs754449459 | T/A | Q108H | Decrease | −0.51365487 | Decrease | 8 | Decrease | −0.262685 |
rs758567125 | A/C | W219G | Decrease | −1.9396669 | Decrease | 9 | Decrease | −2.75964 |
rs767540299 | G/A | R284 W | Decrease | −1.0222554 | Decrease | 4 | Decrease | −0.438376 |
rs772227542 | G/A | L93 F | Decrease | −0.91229984 | Decrease | 8 | Decrease | −1.7408 |
rs773269527 | G/C | P156R | Decrease | −0.63828646 | Decrease | 6 | Decrease | −0.475707 |
rs776488571 | A/C | F136 C | Decrease | −0.23947682 | Decrease | 7 | Decrease | −0.928974 |
rs780705756 | G/A | P107L | Increase | 0.083468873 | Decrease | 4 | Decrease | −0.41095 |