Table 6 Structural validation and RMSD calculation results of all the 23 High‑risk nsSNP mutants by several rigorous analysis tools
From: In-silico analysis of deleterious non-synonymous SNPs in the human AVPR1a gene linked to autism
AA substitution | ERRAT Score | PROCHECK | Alpha Fold | PyMOL | TM Align | |||
|---|---|---|---|---|---|---|---|---|
Core | Allow | Generously | Disallowed | Relax Number | RMSD | TM score | ||
R85H | 91.8182 | 80.3% | 14.2% | 4.0% | 1.6% | 5 | 0.543 | 0.84317 |
D202 N | 93.3131 | 81.4% | 13.8% | 4.3% | 0.5% | 5 | 0.528 | 0.82517 |
E54G | 94.4444 | 80.5% | 15.4% | 2.7% | 1.4% | 5 | 0.440 | 0.78985 |
H92P | 93.2927 | 80.2% | 13.6% | 3.5% | 2.7% | 5 | 0.494 | 0.83291 |
D148Y | 94.7531 | 82.2% | 12.4% | 3.5% | 1.9% | 5 | 0.506 | 0.81940 |
C203G | 90.8012 | 80.8% | 14.1% | 3.8% | 1.4% | 5 | 0.529 | 0.82390 |
V297M | 93.0303 | 81.9% | 13.0% | 3.2% | 1.9% | 5 | 0.543 | 0.82911 |
D148 V | 91.8429 | 80.3% | 14.1% | 4.1% | 1.6% | 5 | 0.562 | 0.81979 |
S182 N | 90.7186 | 81.4% | 13.6% | 3.7% | 1.3% | 5 | 0.529 | 0.83106 |
Q108L | 93.0091 | 80.5% | 14.1% | 3.8% | 1.6% | 5 | 0.502 | 0.82449 |
R149 C | 92.1687 | 81.1% | 13.2% | 4.1% | 1.6% | 5 | 0.601 | 0.81542 |
G212 V | 95.5836 | 80.5% | 15.6% | 2.5% | 1.3% | 5 | 0.529 | 0.82035 |
M145 T | 93.1138 | 81.9% | 13.0% | 3.5% | 1.6% | 5 | 0.463 | 0.81857 |
G212S | 95.4268 | 82.5% | 12.1% | 4.0% | 1.3% | 5 | 0.540 | 0.81713 |
Y140S | 95.2681 | 81.4% | 14.1% | 3.2% | 1.4% | 5 | 0.568 | 0.82421 |
F207 V | 91.4894 | 81.1% | 13.8% | 4.6% | 0.5% | 5 | 0.565 | 0.80465 |
Q108H | 92.5 | 80.1% | 14.2% | 3.8% | 1.9% | 5 | 0.490 | 0.82186 |
W219G | 94.1358 | 80.8% | 13.8% | 4.1% | 1.4% | 5 | 0.510 | 0.82389 |
R284 W | 92.9664 | 82.2% | 12.4% | 3.5% | 1.9% | 5 | 0.589 | 0.82516 |
L93 F | 92.8144 | 81.4% | 12.4% | 4.9% | 1.4% | 5 | 0.482 | 0.83330 |
P156R | 94.3925 | 81.9% | 13.5% | 3.5% | 1.1% | 5 | 0.514 | 0.81200 |
F136 C | 95.1515 | 82.7% | 10.8% | 4.1% | 2.4% | 5 | 0.507 | 0.81425 |
P107L | 94.1935 | 80.8% | 15.4% | 2.0% | 1.9% | 5 | 0.608 | 0.80210 |