Table 1 Nucleotide changes observed during passage of LASV in guinea pigs
From: Genomic changes of Lassa virus associated with mammalian host adaptation
Sample ID | Genome and Nt position | |||||||
|---|---|---|---|---|---|---|---|---|
L | S | |||||||
273 | 773 | 1339 | 2506 | 4891 | 2072 | 2683 | ||
Inoculation virus (GA391) | C | A | T | A | A | G | A | |
Passage 2 | Animal 1 | C | A | C | G | A | G | A |
Animal 2 | C | A | C | G | A | G | A | |
Animal 3 | C | A | C | G | A | G | A | |
Animal 4 | C | A | C | G | A | G | A | |
Animal 5 | C | A | C | G | A | G | A | |
Passage 3 | Animal 1 | C | A | C | G | A | G | A |
Animal 2 | C | A | C | G | A | A | G | |
Animal 3 | C | A | C | G | A | A | G | |
Animal 4 | C | A | C | G | A | G | G | |
Animal 5 | C | A | C | G | A | G | A | |
Passage 4 | Animal 1 | C | A | C | G | A | A | G |
Animal 2 | C | N | N | N | N | A | G | |
Animal 3 | T | N | C | N | A | A | G | |
Animal 4 | T | T | A | G | G | A | G | |
Animal 5 | T | T | C | G | G | A | G | |
Passage 5 | Animal 1 | C | A | C | G | A | A | G |
Animal 2 | C | A | C | G | A | A | G | |
Animal 3 | C | A | C | G | A | A | G | |
Animal 4 | T | T | C | G | G | A | G | |
Animal 5 | T | T | C | G | G | A | G | |
Adapted challenge stock | T | T | C | G | G | A | G | |