Fig. 2

Liver-specific genome-wide enhancer-gene maps landscape. (A-C) Bar charts represent the number of enhancer-gene connections (E-G connections) (A), ABC enhancers (B) and ABC genes (C) in each liver biosample. (D) Cumulative fractions of the number of enhancers predicted to regulate each gene in each liver biosample (black line; mean = 2.0) and the mean number of enhancers predicted to regulate each gene in each liver biosample (red line; median = 2.1). (E) Cumulative fractions of the number of genes regulated by each ABC enhancer in each liver biosample (black line; mean = 3.0) and the mean number of genes regulated by each ABC enhancer in each liver biosample (red line; median = 2.9). (F) Cumulative fractions of the genomic distances between the enhancer and the gene for each predicted enhancer-gene connection in each liver biosample (black line; median = 28,036 bp) and the median genomic distance between each enhancer-gene connection in each liver biosample (red line; median = 33,629 bp). (G) Among all identified ABC genes, 690 (4.1%) were uniquely detected in their respective biosamples. Compared to ABC maps constructed from a single liver biosample (e.g., HepG2_1), this analysis identified an additional 607 ABC genes. ABC, Activity-by-Contact