Fig. 3

Characterization of ABC SNPs. (A) Heatmap shows the genomic distribution of ABC SNPs compared with non-ABC SNPs. P-values were calculated by two-tailed Fisher’s exact test. (B) Heatmap shows the histone modification enrichment of ABC SNPs in regulatory elements including H3K27ac, H3K9ac, H3K4me1, H3K4me3, H3K27me3, and H3K36me3, compared with non-ABC SNPs. P-values were calculated by two-tailed Fisher’s exact test. (C) Heatmap shows the chromatin state enrichment of ABC SNPs compared with non-ABC SNPs. P-values were calculated by two-tailed Fisher’s exact test. (D) Enrichment analyses of ABC SNPs in FinnGen NAFLD-related GWAS SNPs compared with non-ABC SNPs. P-values were calculated by two-tailed Fisher’s exact test and bars indicate 95% CIs. (E) Proportion of GWAS heritability of NAFLD explained by ABC SNPs. The error bars represent standard error. (F) Quantile-quantile (QQ) plots of P values from GWAS of NAFLD. ABC SNPs were shown in comparison with genome-wide SNPs. ABC, Activity-by-Contact; SNP, single nucleotide polymorphism; H3K27ac, H3K27 acetylation marks; H3K9ac, H3K9 acetylation marks; H3K4me1, H3K4 monomethylation marks; H3K4me3, H3K4 trimethylation marks; H3K27me3, H3K27 trimethylation marks; H3K36me3, H3K36 trimethylation marks; NAFLD, non-alcoholic fatty liver disease; TSS, transcription start site; Transcr., transcription; Ehn, enhancers; GWAS, genome-wide association study; OR, odds ratio; CI, confidence interval