Fig. 6

EPHA2 at 1p36.13. (A) The NAFLD GWAS summary statistics were obtained from the FinnGen study. The liver eQTL summary statistics for EPHA2 were downloaded from GTEx v8. The LD values (r²) between the SNP rs1497406 and the other SNPs are based on European populations (from the 1,000 Genomes Project, Phase 3). The colocalization analyses were performed using the R package “coloc” (v5.2.3) and achieved a posterior probability of hypothesis 4 (PP.H4) score of 0.98, suggesting that the eQTLs and GWAS associations were highly likely to colocalize. (B) Drug-gene interaction network indicates the identified drugs of drug-gene interaction analyses from DGIdb targeting EPHA2. EPHA2, EPH receptor A2; NAFLD, non-alcoholic fatty liver disease; GWAS, genome-wide association study; eQTL, expression quantitative trait locus; GTEx, Genotype-Tissue Expression; SNP, single nucleotide polymorphism; LD, linkage disequilibrium; DGIdb, Drug-Gene Interaction Database