Fig. 2

Hierarchical clustering of dexamethasone-induced transcriptional alterations. Relative levels of all transcripts (585) with differential expression are shown as a heat map (Supplementary Table 1). Data were standardized for the expression level in each tissue. Colored rectangles represent transcript abundance 4 h after injection of DEX or CTR in the specific tissue, as indicated below the heatmap. The intensity of the color is proportional to the standardized values (between −4 and 4) from each microarray (according to the scale below the heatmap). Gene clusters are depicted as colors and letters (A-P) on the left. Clustering was performed using Pearson correlation as distance, the results are summarized on the dendrogram shown on the right. Clusters A-F are classified as down-regulated (DOWN). Clusters G-P are classified as up-regulated (UP) in response to DEX