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  1. Long noncoding RNAs (lncRNAs) are versatile regulatory molecules that affect cellular phenotypes through context-specific expression. While their role in controlling cellular pathways is well-established in in...

    Authors: Waseem Akram Malla, Kuldeep Singh, Niha Ayman, Chandini Boro, Naorem Chaoba Devi, Priyanka Mech, Nida Siddiqui, Anupkumar R. Anvikar and Praveen Kumar Bharti
    Citation: BMC Genomics 2025 26:510
    Content type: Research Published on:

  2. N6-methyladenosine (m6A), a prevalent post-transcriptional modification in eukaryotic RNA, plays a significant role in regulating sensory experiences, learning, and injury in the mammalian central nervous syst...

    Authors: Rongrong Zhong, Chen Chen, Yingao Zhang, Conglin Wang, Meimei Li, Fanglian Chen, Lu Wang, Qiang Liu and Ping Lei
    Citation: BMC Genomics 2025 26:509
    Content type: Research Published on:

  3. The pituitary gland, a central regulator of the hypothalamic-pituitary-gonadal (HPG) axis, plays a pivotal role in reproductive efficiency by precisely controlling the secretion of gonadotropins, including fol...

    Authors: Shanglai Li, Bingru Zhao, Peiyong Chen, Yu Cai, Hui Xu, Chenbo Yan, Feng Wang and Yanli Zhang
    Citation: BMC Genomics 2025 26:508
    Content type: Research Published on:

  4. Pneumonia constitutes a major health challenge in sheep, severely compromising growth rates and overall productivity, and resulting in considerable economic losses to the sheep industry. To address this issue,...

    Authors: Kai Huang, Lvfeng Yuan, Jia Liu, Xiaolong Li, Dan Xu, Xiaoxue Zhang, Jie Peng, Huibin Tian, Fadi Li and Weimin Wang
    Citation: BMC Genomics 2025 26:507
    Content type: Research Published on:

  5. Plant basic transcription factor3 (BTF3) plays an important role in photosynthesis rate and plant growth and development. In addition, it is involved in resistance mechanisms related to abiotic and biotic stress ...

    Authors: Ji Won Seo, Da Ye Ham, Jae Geun Lee, Hee Young Kim, Ik Young Choi, Myong Jo Kim and Eun Soo Seong
    Citation: BMC Genomics 2025 26:506
    Content type: Research Published on:

  6. Shaanbei white cashmere goat is an excellent cashmere goat breed, and its market favored cashmere from the secondary hair follicles. Hair follicles mature around birth and each hair follicle repeatedly undergo...

    Authors: Jiamian Du, Menghua Sui, Zhihao Song, Shuangshuang Liang, Yujie Zheng and Xin Wang
    Citation: BMC Genomics 2025 26:505
    Content type: Research Published on:

  7. Oxford Nanopore sequencing is a long-read sequencing technology that does not rely on a polymerase to generate sequence data. Sequencing library preparation methods used in Oxford Nanopore sequencing rely on t...

    Authors: Ziming Chen, Chian Teng Ong, Loan To Nguyen, Harrison J. Lamb, O. González-Recio, M. Gutiérrez-Rivas, Sarah J. Meale and Elizabeth M. Ross
    Citation: BMC Genomics 2025 26:504
    Content type: Research Published on:

  8. Ethylene response factors (ERFs), belonging to the AP2/ERF superfamily, play vital roles in plant growth, development, and stress responses. The evolutionary and expression features of the members of the ERF g...

    Authors: Liwen Wang, Hongjun Zhao, Runfang Li, Rumei Tian, Kaihua Jia, Yongchao Gong, Song Hou, Nana Li and Yanyan Pu
    Citation: BMC Genomics 2025 26:503
    Content type: Research Published on:

  9. To maintain homeostasis in the mature human body, certain differentiated cells adopted high plasticity to refine their cellular functions. However, mechanisms that supported cellular plasticity still remained ...

    Authors: Chao Yu, Jiaxin Huang, Yan Wang, Jia Song and Wei Shen
    Citation: BMC Genomics 2025 26:502
    Content type: Research Published on:

  10. Starch, a major component of wheat (Triticum aestivum L.) grain, plays a crucial role in determining processing quality. Granule-bound starch synthase I (GBSSI), the enzyme primarily responsible for elongating α-...

    Authors: Sujon Kumar, Yulong Li, Jia Zheng, Jing Liu, Qiang Xu, Yazhou Zhang, Huaping Tang, Pengfei Qi, Mei Deng, Jian Ma, Guoyue Chen, Yuming Wei, Youliang Zheng and Qiantao Jiang
    Citation: BMC Genomics 2025 26:501
    Content type: Research Published on:

  11. The epididymis is essential for sperm maturation. During sperm maturation, markable alterations of the payload of small noncoding RNAs are observed in the epididymis, which indicated the role of epigenetic alt...

    Authors: Ziqiang Ding, Xingdong Wang, Shaoke Guo, Yandong Kang, Mengli Cao, Liyan Hu, Ben Zhang, Lin Xiong, Jie Pei, Tao Yang and Xian Guo
    Citation: BMC Genomics 2025 26:500
    Content type: Research Published on:

  12. In insects, the olfactory system governs physiological and behavioral processes by detecting various odorous molecules. Despite its economic importance and adaptability, the olfactory mechanism of Antheraea perny...

    Authors: Xueting Liu, Shuwei Ma, Xinxue Zhang, Xue Li, Lei Nie and Guobao Wang
    Citation: BMC Genomics 2025 26:499
    Content type: Research Published on:

  14. The oriental river prawn Macrobrachium nipponense is widely distributed in China, but its origin and distribution routes remain largely unknown. We collected 126 oriental river prawn specimens from four lakes and...

    Authors: Penghui Luo, Yiting Jin, Ting Zhao, Chao Bian, Zhimin Lv, Na Zhou, Jianguang Qin and Shengming Sun
    Citation: BMC Genomics 2025 26:497
    Content type: Research Published on:

  15. Hundred-kernel weight (HKW) is a crucial determinant of maize yield. Understanding the genetic mechanisms underlying HKW is vital for maize breeding programs aimed at enhancing productivity. This study aimed t...

    Authors: Mengfei Shi, Fuyan Jiang, Ranjan K. Shaw, Babar Ijaz, Jiachen Sun and Xingming Fan
    Citation: BMC Genomics 2025 26:496
    Content type: Research Published on:

  16. Long-term geographical isolation and the different directions of domestication can cause a large number of genome variations. Population genetic analysis based on a single reference genome cannot capture all t...

    Authors: Xu Wang, Ming Yan, Shanshan Cui, Fang Li, Qingqing Zhao, Qingnan Wang, Bin Jiang, Yixin Huang, Yang Sun and Xiangdong Kong
    Citation: BMC Genomics 2025 26:495
    Content type: Research Published on:

  17. The cytochrome P450 superfamily comprises a large group of enzymes crucial for the biosynthesis and metabolism of diverse endogenous and exogenous secondary metabolites in plants. Chrysanthemum, an ornamental gen...

    Authors: Yuyuan Chen, Tongjun Zhou, Jian Zhong, Yuxian Xu, Peng Zhang, Xiaoyu Yue, Hua Zhang, Ming Sun and Xuehao Fu
    Citation: BMC Genomics 2025 26:494
    Content type: Research Published on:

  18. Non-alcoholic fatty liver disease (NAFLD) represents the most widespread liver disease globally, ranging from non-alcoholic fatty liver (NAFL) and steatohepatitis (NASH) to fibrosis/cirrhosis, with potential p...

    Authors: Ruofan Li, Kaiyan Su, Tianzhun Wu, Li Xu, Wenyu Song, Dandan Sun, Tao Zeng, Jinzhang Chen, Haibei Xin, Yuanfeng Li, Mengya Zang and Minggen Hu
    Citation: BMC Genomics 2025 26:493
    Content type: Research Published on:

  19. Single nucleotide polymorphisms are the most prevalent type of DNA variation occurring at a single nucleotide within the genomic sequence. The AVPR1a gene exhibits genetic polymorphism and is linked to neurologic...

    Authors: Md. Delowar Kobir Jibon, Md. Asadul Islam, Md. Eram Hosen, Md. Omar Faruqe, Rashed Zaman, Uzzal Kumar Acharjee, Biswanath Sikdar, Yewulsew Kebede Tiruneh, Md. Khalekuzzaman, Motasim Jawi and Magdi E. A. Zaki
    Citation: BMC Genomics 2025 26:492
    Content type: Research Published on:

  20. The present study was conducted to investigate the possible mutagenic effects of picric acid on the chloroplast genome and certain biological properties of Brassica napus L. under field conditions. The experiment...

    Authors: Ishtiaq Ahmad, Barkat Ullah, Zahir Muhammad, Dikhnah Alshehri, Muhammad Nauman Khan, Alevcan Kaplan, Majid Iqbal, Laila A. Al-Shuraym, Uthman Balgith Algopishi, Sadeq K. Alhag, Meshari A. Alsuwat, Diriba Dereje Olana, Muhammad Ammar Javed and Sarah Abdul Razak
    Citation: BMC Genomics 2025 26:491
    Content type: Research Published on:

  21. Camellia tachangensis F. C. Zhang is an endemic Camellia species of the junction of Yunnan, Guizhou and Guangxi Provinces in China. It is characterized by a primitive five-chambered ovary morphology and serves as...

    Authors: Dongzhen Jiang, Lei Zhou, Zhaohui Ran, Xu Xiao, Xuehang Yang and Zhi Li
    Citation: BMC Genomics 2025 26:490
    Content type: Research Published on:

  22. Lassa virus (LASV) causes a severe haemorrhagic fever in humans, with estimates of 100,000 to 300,000 infections annually in endemic regions and accounting for around 5000 deaths. The natural reservoir is the Mas...

    Authors: Linda Easterbrook, Xiaofeng Dong, Jack Smith, Susan Fotheringham, Sarah Kempster, Catherine Hartley, Tessa Prince, Victoria Graham, Emma Kennedy, Stephen Findlay-Wilson, Lucy Crossley, Roger Hewson, Neil Almond, Julian A. Hiscox and Stuart Dowall
    Citation: BMC Genomics 2025 26:489
    Content type: Research Published on:

  23. Contagious ecthyma is an acute infectious zoonosis caused by orf virus (ORFV). Live-attenuated ORFV vaccines have played a crucial role in preventing contagious ecthyma for decades. However, these vaccines oft...

    Authors: Tian Jing, Yunpeng Wang, Yukun Bu, Xi Chen, Shutong Feng, Wenbo Liu, Zhannur Niyazbekova, Dekun Chen, Xiaolong Gao and Wentao Ma
    Citation: BMC Genomics 2025 26:488
    Content type: Research Published on:

  24. Cashmere goats, as one of the important domesticated animal species, are known for their high-quality fiber. The growth of cashmere has seasonal variations caused by photoperiodic changes, but the molecular ge...

    Authors: Min Yang, Yingying Li, Qianqian Liang, Huajiao Dong, Yuehui Ma, Göran Andersson, Erik Bongcam-Rudloff, Hafiz Ishfaq Ahmad, Xuefeng Fu and Jilong Han
    Citation: BMC Genomics 2025 26:487
    Content type: Research Published on:

  25. Intertidal organisms withstand extreme temperature fluctuations, and theirability to cope with this variation may affect their distributions across the seascape. Genetic variation and local environments likely...

    Authors: D. M. Wuitchik, J. E. Fifer, A. K. Huzar, J. A. Pechenik, L. H. Uricchio and S. W. Davies
    Citation: BMC Genomics 2025 26:486
    Content type: Research Published on:

  27. Topologically associating domains (TADs) are functional units that organize chromosomes into 3D structures of interacting chromatin, and play a crucial role in regulating gene expression by constraining enhanc...

    Authors: Hongwei Yin, Qianyi Zhao, Liu Yang, Guoqiang Yi, Wenye Yao, Lingzhao Fang and Lijing Bai
    Citation: BMC Genomics 2025 26:484
    Content type: Research Published on:

  28. Coral reefs are being increasingly threatened due to global climate change. However, some coral species have shown strong tolerance despite living in marginal environments. The species Pavona decussata from Weizh...

    Authors: Man Zhang, Shan Huang, Li Luo and Kefu Yu
    Citation: BMC Genomics 2025 26:483
    Content type: Research Published on:

  29. While the size of chromosomes can be measured under a microscope, obtaining the exact size of a genome remains a challenge. Biochemical methods and k-mer distribution-based approaches allow only estimations. A...

    Authors: Shakunthala Natarajan, Jessica Gehrke and Boas Pucker
    Citation: BMC Genomics 2025 26:482
    Content type: Research Published on:

  30. Runs of homozygosity (ROH) have been extensively investigated to uncover the genomic inbred regions that reflect past population and breeding histories. In this study, we have explored the distribution and num...

    Authors: Qianqian Zhang, Wenjun Lv, Defu Liu, Xueying Xie, Ke Yang, You Tang and Johann Solkner
    Citation: BMC Genomics 2025 26:481
    Content type: Research Published on:

  31. Pinan cattle, as the progeny of crossbreeding improvement between Nanyang cattle and Piedmontese, have attracted attention for their excellent growth performance. In this study, we constructed a copy number va...

    Authors: Xingya Song, Zijing Zhang, Shengyan Xing, Xian Liu, Yuqiao Zhang, Jiamei Wang, Shijie Lyu, Xiangnan Wang, Xingshan Qi, Weidong Ma, Chuzhao Lei, Eryao Wang and Yongzhen Huang
    Citation: BMC Genomics 2025 26:480
    Content type: Research Published on:

  32. The LCORL-NCAPG locus is a major quantitative trait locus (QTL) on bovine chromosome 6 (BTA6) that influences growth and carcass composition in cattle. To further understand the molecular mechanism responsible fo...

    Authors: Fernanda Martins Rodrigues, Leif E. Majeres, Anna C. Dilger, Joshua C. McCann, Christopher J. Cassady, Dan W. Shike and Jonathan E. Beever
    Citation: BMC Genomics 2025 26:479
    Content type: Research Published on:

  33. The temperature of testes exposed to hyperthermic conditions can affect livestock reproductive performance. This study aimed to explore the difference in semen quality, testicular morphological structure, and ...

    Authors: Haisheng Ding, Yuanlang Wang, Huiling Zhao, Jinzi Wang and Dongwei Huang
    Citation: BMC Genomics 2025 26:478
    Content type: Research Published on:

  34. Yellow lupin (Lupinus luteus) gives valuable high-quality protein and has good sustainability due to its ability in nitrogen fixation and exudation of organic acids, which reduces the need for chemical-based phos...

    Authors: J. Eduardo Martinez-Hernandez, Haroldo Salvo-Garrido, Daniela Levicoy, Peter D. S. Caligari, Annally Rupayán, Tomas Moyano, Makarena Carrasco, Sebastián Hernandez, Grace Armijo-Godoy, Fernando Westermeyer and Giovanni Larama
    Citation: BMC Genomics 2025 26:477
    Content type: Research Published on:

  35. Abnormal deposition of melanin in skeletal muscle is an interesting phenomenon and the Silkie is the most typical example. Melanin deposition involves multiple steps such as neural crest cell migration, melano...

    Authors: Xinting Yang, Bowen Ma, Qingyu Zhao, Yaxiong Jia, Qingshi Meng, Yuchang Qin, Chaohua Tang and Junmin Zhang
    Citation: BMC Genomics 2025 26:476
    Content type: Research Published on:

  36. The Chinese giant salamander (CGS, Andrias davidianus), a flagship amphibian species, is highly vulnerable to high temperatures, posing a significant threat under future climate change. Previous research linked t...

    Authors: Runliang Zhai, Chunlin Zhao, Liming Chang, Jiongyu Liu, Tian Zhao, Jianping Jiang and Wei Zhu
    Citation: BMC Genomics 2025 26:475
    Content type: Research Published on:

  38. Genomic repetitive DNA sequences (Repeatomes, REPs) are widespread in eukaryotes, influencing biological form and function. In Cnidaria, an early-diverging animal lineage, these sequences remain largely unchar...

    Authors: Jeferson A. Durán-Fuentes, Maximiliano M. Maronna, Octavio M. Palacios-Gimenez, Elio R. Castillo, Joseph F. Ryan, Marymegan Daly and Sérgio N. Stampar
    Citation: BMC Genomics 2025 26:473
    Content type: Research Published on:

  39. Coccinellini lady beetles have been applied as biological control agent of aphids, however, not all of these species are obligately aphidophagous. Thus, a comprehensive understanding of the molecular mechanism...

    Authors: Xuefei Tang, Xinhui Xia, Yuqi Liu, Xiyao Hong, Yuhao Huang, Guannan Li, Yuansen Liang, Xueqing Wang, Hong Pang and Yuchen Yang
    Citation: BMC Genomics 2025 26:472
    Content type: Research Published on:

  40. The regulatory roles of non-coding RNAs (ncRNAs) during sex differentiation in teleosts have received widespread attention recently. Mifepristone (RU486, a progesterone antagonist), which acts as an endocrine ...

    Authors: Rui Gao, Hongwei Yan, Huiting Zhou, Mingtao Hu, Jia Wang, Xufang Shen, Meiyuan Li, Jinfeng Chen, Qi Liu, Ying Liu, Xiuli Wang, Qunwen Sun and He Zhou
    Citation: BMC Genomics 2025 26:471
    Content type: Research Published on:

  41. Heat stress, exacerbated by global warming, has emerged as a significant concern for both the health of dairy cattle and the quality of milk production. In vitro investigations suggest that primary bovine mamm...

    Authors: Siqi Xia, Huimei Fan, Jianghai Xiao, Ci Shen, Yongping Yan, Meigui Wang, Tao Tang, Wenqiang Sun, Jie Wang, Xianbo Jia and Songjia Lai
    Citation: BMC Genomics 2025 26:470
    Content type: Research Published on:

  42. Growth traits are economically important traits in pig breeding. However, the genetic mechanism of growth traits is still unclear. Qinchuan Black (QCB) pigs are crossbred and produced by hybridizing Guanzhong ...

    Authors: Yaxin Wang, Guangquan Lv, Zhe Liu, Ye Cheng, Rongrong Ding, Gongshe Yang and Taiyong Yu
    Citation: BMC Genomics 2025 26:469
    Content type: Research Published on:

  43. Ancylostoma duodenale, a parasitic nematode worm, is found to be involved in various infections, including intestinal blood loss, protein malnutrition, and anemia. Antimicrobial resistance to the available therap...

    Authors: Mohibullah Shah, Hira Anum, Asifa Sarfraz, Md. Aktaruzzaman, Al Riyad Hasan, Muhammad Umer Khan, Khaled Fahmi Fawy, Sarah A. Altwaim, Saeed M. N. Alasmari, Abid Ali, Umar Nishan and Ke Chen
    Citation: BMC Genomics 2025 26:468
    Content type: Research Published on:

  44. A number of studies show that combining somatic embryogenesis with environmental stimuli can induce plant defenses against abiotic stresses, offering a complementary strategy in tree breeding programs. In a pr...

    Authors: Javier Montero-Pau, María Amparo Pérez-Oliver, Álvaro Rodríguez-Cuesta, Isabel Arrillaga and Ester Sales
    Citation: BMC Genomics 2025 26:467
    Content type: Research Published on:

  45. The accumulation of tail fat in sheep is a manifestation of adaptive evolution to the environment. Sheep with different tail types show significant differences in physiological functions and tail fat depositio...

    Authors: Wannian Wang, Zhixv Pang, Siying Zhang, Pengkun Yang, Yangyang Pan, Liying Qiao, Kaijie Yang, Jianhua Liu, Ruizhen Wang and Wenzhong Liu
    Citation: BMC Genomics 2025 26:465
    Content type: Research Published on:

  46. Heat stress seriously affects the production and health of dairy cows and is a key factor limiting the sustainable development of the dairy industry. DNA methylation serves as an important epigenetic regulator...

    Authors: Yuze Yang, Yumei Chen, Lirong Hu, Congcong Zhang, Gong Chen, Lingling Hou, Qing Xu, Yachun Wang and Min Li
    Citation: BMC Genomics 2025 26:464
    Content type: Research Published on:

  47. Pitaya is an important tropical fruit highly favoured by consumers owing to its good and juicy characteristics. It contains a large amount of betacyanin, which is a natural food-colouring agent, in the peel an...

    Authors: Enting Zheng, Gulbar Yisilam, Chuanning Li, Fangfang Jiao, Yulan Ling, Shuhua Lu, Qiuyan Wang and Xinmin Tian
    Citation: BMC Genomics 2025 26:463
    Content type: Research Published on:

  48. Glucocorticoids, acting through the glucocorticoid receptor (GR), control metabolism, maintain homeostasis, and enable adaptive responses to environmental challenges. Their function has been comprehensively st...

    Authors: Marcin Piechota, Mateusz Zieba, Małgorzata Borczyk, Slawomir Golda, Jacek Hajto, Urszula Skupio, Michal Slezak, Jan Rodriguez Parkitna and Michal Korostynski
    Citation: BMC Genomics 2025 26:462
    Content type: Research Published on:

  49. Lotus (Nelumbo nucifera Gaertn.) is an ancient relic plant that has applications as an aquatic flower, herbal medicine, and vegetable. It is responsive to environmental stress. Calcium functions as a ubiquitous s...

    Authors: Teng Cheng, Mengyang Li, Chufeng Zhao, Tao Wang, Xingwen Zheng, Liangbo Yang, Ying Diao, Sai Yang and Zhongli Hu
    Citation: BMC Genomics 2025 26:461
    Content type: Research Published on:

  50. In this study, we present the first chromosome-scale genome of Verpa penis (Linnaeus, 1758), and the first for the bivalve clade Anomalodesmata. The present study has two separate foci. Primarily, we provide the ...

    Authors: Julia D. Sigwart, Nur Leena W.S. Wong, Vanessa Liz González, Fabrizio Marcondes Machado, Carola Greve, Tilman Schell and Zeyuan Chen
    Citation: BMC Genomics 2025 26:460
    Content type: Research Published on:

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BMC Genomics

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